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Crystal structure of M. tuberculosis glutamine-dependent NAD+ synthetase complexed with Sulfonamide derivative 1, pyrophosphate, and glutamine

Source organism: Mycobacterium tuberculosis CDC1551
Biochemical function: identical protein binding
Biological process: NAD biosynthetic process
Cellular component: peptidoglycan-based cell wall

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EC 6.3.5.1: NAD(+) synthase (glutamine-hydrolyzing)

Reaction catalysed:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
Systematic name:
Deamido-NAD(+):L-glutamine amido-ligase (AMP-forming)
Alternative Name(s):
  • DPN synthetase
  • Desamidonicotinamide adenine dinucleotide amidotransferase
  • NAD synthetase (glutamine-hydrolyzing)
  • NAD(+) synthetase (glutamine-hydrolyzing)
  • Nicotinamide adenine dinucleotide synthetase (glutamine)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02540
Domain description: NAD synthase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
The deposited structure of PDB entry 6ofc contains 4 copies of Pfam domain PF02540 (NAD synthase) in Glutamine-dependent NAD(+) synthetase. Showing 1 copy in chain B.

PF00795
Domain description: Carbon-nitrogen hydrolase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
The deposited structure of PDB entry 6ofc contains 4 copies of Pfam domain PF00795 (Carbon-nitrogen hydrolase) in Glutamine-dependent NAD(+) synthetase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003010
Domain description: Carbon-nitrogen hydrolase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR003694
Domain description: NAD(+) synthetase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR014445
Domain description: Glutamine-dependent NAD(+) synthetase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR036526
Domain description: Carbon-nitrogen hydrolase superfamily
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR041856
Domain description: Glutamine-dependent NAD+ synthetase, C-terminal
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR022310
Domain description: NAD/GMP synthase
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Glutamine-dependent NAD(+) synthetase

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