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Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyridine 4

X-ray diffraction
2.21Å resolution
PDB entry 6mda coloured by chain, front view.
PDB entry 6mda coloured by chain, side view.
PDB entry 6mda coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11
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Multimeric state: monomeric
Accessible surface area: 21049.97 Å2
Buried surface area: 174.47 Å2
Dissociation area: 87.23 Å2
Dissociation energy (ΔGdiss): 5.75 kcal/mol
Dissociation entropy (TΔSdiss): 0.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170287
Assembly 2
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11
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Multimeric state: monomeric
Accessible surface area: 20811.12 Å2
Buried surface area: 206.16 Å2
Dissociation area: 103.08 Å2
Dissociation energy (ΔGdiss): 9.45 kcal/mol
Dissociation entropy (TΔSdiss): 0.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170287

Macromolecules

Tyrosine-protein phosphatase non-receptor type 11
Chains: A, B
Length: 526 amino acids
Theoretical weight: 60.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-525; Coverage: 89%)
Gene names: PTP2C, PTPN11, SHPTP2
Pfam:
InterPro:
CATH:
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 6mda, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 6mda, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 6mda, assembly 1, top view.
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