Function and Biology

Structure of SETD3 bound to SAH and unmodified actin

Source organism: Homo sapiens
Biochemical function: protein-L-histidine N-tele-methyltransferase activity
Biological process: actin modification
Cellular component: not assigned

EC 2.1.1.85: Protein-histidine N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine
Systematic name:
S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase
Alternative Name(s):
  • Actin-specific histidine methyltransferase
  • Protein (histidine) methyltransferase
  • Protein methylase IV
  • S-adenosyl methionine:protein-histidine N-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF09273
Domain description: Rubisco LSMT substrate-binding
Occurring in:
  1. Actin-histidine N-methyltransferase
The deposited structure of PDB entry 6icv contains 2 copies of Pfam domain PF09273 (Rubisco LSMT substrate-binding) in Actin-histidine N-methyltransferase. Showing 1 copy in chain A.

PF00856
Domain description: SET domain
Occurring in:
  1. Actin-histidine N-methyltransferase
The deposited structure of PDB entry 6icv contains 2 copies of Pfam domain PF00856 (SET domain) in Actin-histidine N-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036464
Domain description: Rubisco LSMT, substrate-binding domain superfamily
Occurring in:
  1. Actin-histidine N-methyltransferase
IPR001214
Domain description: SET domain
Occurring in:
  1. Actin-histidine N-methyltransferase
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin, cytoplasmic 1, N-terminally processed
IPR015353
Domain description: Rubisco LSMT, substrate-binding domain
Occurring in:
  1. Actin-histidine N-methyltransferase
IPR044428
Domain description: SETD3, SET domain
Occurring in:
  1. Actin-histidine N-methyltransferase
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Actin-histidine N-methyltransferase
IPR025785
Domain description: Actin-histidine N-methyltransferase SETD3
Occurring in:
  1. Actin-histidine N-methyltransferase