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Crystal structure of human anti-tau antibody CBTAU-27.1

X-ray diffraction
1.9Å resolution
PDB entry 6dcv coloured by chain, front view.
PDB entry 6dcv coloured by chain, side view.
PDB entry 6dcv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 19973.26 Å2
Buried surface area: 4480.06 Å2
Dissociation area: 2,104.57 Å2
Dissociation energy (ΔGdiss): 23.46 kcal/mol
Dissociation entropy (TΔSdiss): 13.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134615
Assembly 2 (preferred)
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Assembly Name: IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 19791.57 Å2
Buried surface area: 4390.99 Å2
Dissociation area: 2,098.29 Å2
Dissociation energy (ΔGdiss): 24.06 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134615

Macromolecules

Immunoglobulin kappa constant
Chains: A, L
Length: 220 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Best match: P01834 (Residues: 1-107)
Gene name: IGKC
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, front view.
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, side view.
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, top view.
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Immunoglobulin heavy constant gamma 1
Chains: B, H
Length: 231 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Best match: P01857 (Residues: 1-107)
Gene name: IGHG1
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, top view.
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