› 6zwc

X-ray diffraction
2.04Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-160570 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tubulin alpha-1B chain Chain: A
Molecule details ›
Chain: A
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-451; Coverage: 100%)
Sequence domains:
Tubulin beta-2B chain Chain: B
Molecule details ›
Chain: B
Length: 445 amino acids
Theoretical weight: 50 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-445; Coverage: 100%)
Gene name: TUBB2B
Sequence domains:
Designed Ankyrin Repeat Protein (DARPIN) D1 Chain: F
Molecule details ›
Chain: F
Length: 169 amino acids
Theoretical weight: 18.07 KDa
Source organism: synthetic construct
Expression system: synthetic construct

Ligands and Environments

4 bound ligands:
Ligand GTP 1 x GTP
Ligand MG 1 x MG
Ligand GDP 1 x GDP
Ligand QRQ 1 x QRQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 73.9Å b: 91.85Å c: 82.81Å
α: 90° β: 96.58° γ: 90°
R-values:
R R work R free
0.227 0.225 0.282
Expression system: synthetic construct

Quick links

Citations

4 review citations

Molecular photoswitches in aqueous environments.
Volarić et al. (2021)
3 more

3 mentions without citation

Photopharmacology of Antimitotic Agents.
Kirchner et al. (2022)
2 more