Tubulin/FtsZ, GTPase domain superfamily (IPR036525)
Short name: Tubulin/FtsZ_GTPase_sf
- Cell division protein FtsZ (IPR000158)
- Tubulin (IPR000217)
- Alpha tubulin (IPR002452)
- Beta tubulin (IPR002453)
- Gamma tubulin (IPR002454)
- Delta tubulin (IPR002967)
- Tubulin/FtsZ, GTPase domain (IPR003008)
- Epsilon tubulin (IPR004057)
- Zeta tubulin (IPR004058)
- DML1/Misato, tubulin domain (IPR029209)
- Tubulin-like protein CetZ (IPR032907)
This entry represents a GTPase domain found in all tubulin chains, such as tubulin alpha, beta and gamma chains, and some bacterial FtsZ proteins [PMID: 9628483]. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells [PMID: 9144213, PMID: 9428770]. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings invitro and isubiquitous in bacteria and archaea.
The structure of the GTPase domain has a three layers (alpha/beta/alpha) with a parallel beta-sheet of six strands.