› 6nrw

X-ray diffraction
2.4Å resolution

Crystal structure of Dpr1 IG1 bound to DIP-eta IG1

Released:
DOI: 10.2210/pdb6nrw/pdb
PDB entry 6nrw coloured by chain, front view.
PDB entry 6nrw coloured by chain, side view.
PDB entry 6nrw coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Özkan E
OpenAccess logo Elife 8 (2019)
PMID: 30688651

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186129 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Ig-like domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 114 amino acids
Theoretical weight: 13.24 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8T603 (Residues: 51-155; Coverage: 29%)
Gene names: CG13439, dpr, dpr1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 112 amino acids
Theoretical weight: 12.94 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9VMN9 (Residues: 40-143; Coverage: 25%)
Gene names: 14010, CG14010, CT33567, DIP-eta, Dmel\CG14010, Dmel_CG14010
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand SO4 3 x SO4
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P43212
Unit cell:
a: 74.084Å b: 74.084Å c: 235.445Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.244
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
4 more

1 mention without citation

DIP/Dpr interactions and the evolutionary design of specificity in protein families.
Sergeeva et al. (2020)