6att

X-ray diffraction
3.77Å resolution

39S Fab bound to HER2 ecd

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-230793 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Receptor tyrosine-protein kinase erbB-2 Chain: A
Molecule details ›
Chain: A
Length: 630 amino acids
Theoretical weight: 69.42 KDa
Source organism: Homo sapiens
Expression system: Mammalian expression vector pBGSA
UniProt:
  • Canonical: P04626 (Residues: 23-652; Coverage: 51%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains:
Antibody 39S Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 23.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody 39S Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 67.327Å b: 108.172Å c: 348.308Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.251 0.289
Expression systems:
  • Mammalian expression vector pBGSA
  • Homo sapiens