› 5z5u

X-ray diffraction
1.63Å resolution

The first bromodomain of BRD4 with compound BDF-2254

Released:
DOI: 10.2210/pdb5z5u/pdb
PDB entry 5z5u coloured by chain, front view.
PDB entry 5z5u coloured by chain, side view.
PDB entry 5z5u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Chen W, Zhang H, Chen Z, Jiang H, Liao L, Fan S, Xing J, Xie Y, Chen S, Ding H, Chen K, Jiang H, Luo C, Zheng M, Yao Z, Huang Y, Zhang Y
OpenAccess logo Oncogenesis 7 83 (2018)
PMID: 30385738

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-167; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 96U 1 x 96U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 32.006Å b: 47.276Å c: 78.794Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.215
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Artificial Intelligence in Renal Cell Carcinoma Histopathology: Current Applications and Future Perspectives.
Distante et al. (2023)
1 more

1 mention without citation

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Chen et al. (2018)