PDB 5xrd biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric

Accessible surface area: 10167.86 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-139817

$Monomeric assembly 1 of PDB entry 5xrd coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>1 copy of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5xrd coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>1 copy of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5xrd coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>1 copy of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: homo dimer

Accessible surface area: 18729.23 Å²

Buried surface area: 1604.68 Å²

Dissociation area: 802.34 Å²

Dissociation energy (ΔG^diss): 1.9 kcal/mol

Dissociation entropy (TΔS^diss): 12.72 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-139824

$Homo dimeric assembly 2 of PDB entry 5xrd coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>2 copies of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 5xrd coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>2 copies of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 5xrd coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Heat shock protein HSP 90-alpha;</li> <li class='image_legend_li'>2 copies of N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1H-pyrazol-5-yl}acetamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

Macromolecules

Heat shock protein HSP 90-alpha

Chain: A
Length: 228 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P07900 (Residues: 9-236; Coverage: 31%)

Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:

Histidine kinase/HSP90-like ATPase superfamily
Heat shock protein Hsp90 family
Heat shock protein Hsp90, N-terminal
Heat shock protein Hsp90, conserved site
Histidine kinase/HSP90-like ATPase

Heat shock protein HSP 90-alpha in PDB entry 5xrd, assembly 1, front view.

Heat shock protein HSP 90-alpha in PDB entry 5xrd, assembly 1, side view.

Heat shock protein HSP 90-alpha in PDB entry 5xrd, assembly 1, top view.

FASTA Sequence


    >pdb|5xrd|A

DQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE

PDBe-KB: UniProt Coverage View: P07900

Molecule details ›

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FASTA (Protein chains A)
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Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P07900 (UniProt)

Protein Data Bank in Europe

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 5xrd › Structure analysis

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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5xrd › Structure analysis