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Crystal structure of phosphoglycerate mutase from Naegleria fowleri

Source organism: Naegleria fowleri
Biochemical function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Biological process: glycolytic process
Cellular component: not assigned

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EC 5.4.2.11: Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)

Reaction catalysed:
(1a) [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-N(tau)-phospho-L-histidine + 2/3-phospho-D-glycerate
Systematic name:
D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-dependent)
Alternative Name(s):
  • 2,3-diphosphoglycerate dependent phosphoglycerate mutase
  • Cofactor dependent phosphoglycerate mutase
  • DPGM
  • Glycerate phosphomutase (diphosphoglycerate cofactor)
  • GriP mutase
  • MPGM
  • Monophosphoglycerate mutase
  • Monophosphoglyceromutase
  • PGA mutase
  • PGAM
  • PGAM-d
  • PGM
  • Phosphoglycerate phosphomutase
  • Phosphoglyceromutase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00300
Domain description: Histidine phosphatase superfamily (branch 1)
Occurring in:
  1. Phosphoglycerate mutase
The deposited structure of PDB entry 5vve contains 4 copies of Pfam domain PF00300 (Histidine phosphatase superfamily (branch 1)) in Phosphoglycerate mutase. Showing 2 copies in chain B.

InterPro InterPro annotations
IPR013078
Domain description: Histidine phosphatase superfamily, clade-1
Occurring in:
  1. Phosphoglycerate mutase
IPR005952
Domain description: Phosphoglycerate mutase 1
Occurring in:
  1. Phosphoglycerate mutase
IPR029033
Domain description: Histidine phosphatase superfamily
Occurring in:
  1. Phosphoglycerate mutase
IPR001345
Domain description: Phosphoglycerate/bisphosphoglycerate mutase, active site
Occurring in:
  1. Phosphoglycerate mutase

Structure domain

CATH CATH domain
3.40.50.1240
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Phosphoglycerate mutase-like
Occurring in:
  1. Phosphoglycerate mutase
The deposited structure of PDB entry 5vve contains 2 copies of CATH domain 3.40.50.1240 (Rossmann fold) in Phosphoglycerate mutase. Showing 1 copy in chain B.

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