› › Structure analysis

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dTTP

X-ray diffraction
1.861Å resolution
PDB entry 5tf8 coloured by chain, front view.
PDB entry 5tf8 coloured by chain, side view.
PDB entry 5tf8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cystic fibrosis transmembrane conductance regulator
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 10820.47 Å2
Buried surface area: 747.04 Å2
Dissociation area: 78.95 Å2
Dissociation energy (ΔGdiss): 11.61 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146638

Macromolecules

Cystic fibrosis transmembrane conductance regulator
Chain: A
Length: 229 amino acids
Theoretical weight: 25.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P13569 (Residues: 387-646; Coverage: 15%)
Gene names: ABCC7, CFTR
Pfam: ABC transporter
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tf8, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tf8, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tf8, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links