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PanDDA analysis group deposition -- Crystal Structure of DCLRE1A after initial refinement with no ligand modelled (structure 173)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF07522
Domain description: DNA repair metallo-beta-lactamase
Occurring in:
  1. DNA cross-link repair 1A protein
The deposited structure of PDB entry 5q70 contains 1 copy of Pfam domain PF07522 (DNA repair metallo-beta-lactamase) in DNA cross-link repair 1A protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. DNA cross-link repair 1A protein
IPR011084
Domain description: DNA repair metallo-beta-lactamase
Occurring in:
  1. DNA cross-link repair 1A protein

Structure domains

CATH CATH domains
3.60.15.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Metallo-beta-lactamase; Chain A
Homology: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. DNA cross-link repair 1A protein
The deposited structure of PDB entry 5q70 contains 1 copy of CATH domain 3.60.15.10 (Metallo-beta-lactamase; Chain A) in DNA cross-link repair 1A protein. Showing 1 copy in chain A.
3.40.50.12650
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. DNA cross-link repair 1A protein
The deposited structure of PDB entry 5q70 contains 1 copy of CATH domain 3.40.50.12650 (Rossmann fold) in DNA cross-link repair 1A protein. Showing 1 copy in chain A.

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