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Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with an (R)-methyl substitued Fasudil-derivative.

X-ray diffraction
1.488Å resolution
PDB entry 5m71 coloured by chain, front view.
PDB entry 5m71 coloured by chain, side view.
PDB entry 5m71 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha and cAMP-dependent protein kinase inhibitor alpha
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Multimeric state: hetero dimer
Accessible surface area: 17279.28 Å2
Buried surface area: 1895.73 Å2
Dissociation area: 898.18 Å2
Dissociation energy (ΔGdiss): 1.51 kcal/mol
Dissociation entropy (TΔSdiss): 9.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150425

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 353 amino acids
Theoretical weight: 41.11 KDa
Source organism: Cricetulus griseus
Expression system: Escherichia coli
UniProt:
  • Canonical: P25321 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5m71, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5m71, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5m71, assembly 1, top view.
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cAMP-dependent protein kinase inhibitor alpha
Chain: B
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61925 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5m71, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5m71, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5m71, assembly 1, top view.
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