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IQGAP1 calponin homology domain fragment (CHDF) mutant K161C under oxidizing conditions

X-ray diffraction
2.36Å resolution
PDB entry 5l0o coloured by chain, front view.
PDB entry 5l0o coloured by chain, side view.
PDB entry 5l0o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ras GTPase-activating-like protein IQGAP1
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Multimeric state: homo dimer
Accessible surface area: 16643.88 Å2
Buried surface area: 1365.82 Å2
Dissociation area: 682.91 Å2
Dissociation energy (ΔGdiss): 3.81 kcal/mol
Dissociation entropy (TΔSdiss): 12.36 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155564
Assembly 2
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Assembly Name: Ras GTPase-activating-like protein IQGAP1
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Multimeric state: homo dimer
Accessible surface area: 16670.38 Å2
Buried surface area: 1434.2 Å2
Dissociation area: 717.1 Å2
Dissociation energy (ΔGdiss): 2.76 kcal/mol
Dissociation entropy (TΔSdiss): 12.37 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155564

Macromolecules

Ras GTPase-activating-like protein IQGAP1
Chains: A, B, C, D
Length: 193 amino acids
Theoretical weight: 22.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46940 (Residues: 1-191; Coverage: 12%)
Gene names: IQGAP1, KIAA0051
Pfam: Calponin homology (CH) domain
InterPro:
CATH: Calponin-like domain
Ras GTPase-activating-like protein IQGAP1 in PDB entry 5l0o, assembly 1, front view.
Ras GTPase-activating-like protein IQGAP1 in PDB entry 5l0o, assembly 1, side view.
Ras GTPase-activating-like protein IQGAP1 in PDB entry 5l0o, assembly 1, top view.
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