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Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 10mM Ca2+

X-ray diffraction
2.463Å resolution
PDB entry 5hxr coloured by chain, front view.
PDB entry 5hxr coloured by chain, side view.
PDB entry 5hxr coloured by chain, top view.
Source organism: Methanocaldococcus jannaschii DSM 2661
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Uncharacterized membrane protein MJ0091
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Multimeric state: monomeric
Accessible surface area: 13767.83 Å2
Buried surface area: 3650.64 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-176431

Macromolecules

Uncharacterized membrane protein MJ0091
Chain: A
Length: 300 amino acids
Theoretical weight: 32.03 KDa
Source organism: Methanocaldococcus jannaschii DSM 2661
Expression system: Escherichia coli
UniProt:
  • Canonical: Q57556 (Residues: 1-300; Coverage: 99%)
Gene name: MJ0091
Pfam: Sodium/calcium exchanger protein
InterPro:
CATH:
Uncharacterized membrane protein MJ0091 in PDB entry 5hxr, assembly 1, front view.
Uncharacterized membrane protein MJ0091 in PDB entry 5hxr, assembly 1, side view.
Uncharacterized membrane protein MJ0091 in PDB entry 5hxr, assembly 1, top view.
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