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Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.

X-ray diffraction
2.65Å resolution
PDB entry 5fdx coloured by chain, front view.
PDB entry 5fdx coloured by chain, side view.
PDB entry 5fdx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Epithelial discoidin domain-containing receptor 1
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Multimeric state: monomeric
Accessible surface area: 14142.12 Å2
Buried surface area: 761.67 Å2
Dissociation area: 208.74 Å2
Dissociation energy (ΔGdiss): -6.72 kcal/mol
Dissociation entropy (TΔSdiss): 2.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170636
Assembly 2 (preferred)
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Assembly Name: Epithelial discoidin domain-containing receptor 1
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Multimeric state: monomeric
Accessible surface area: 14220.93 Å2
Buried surface area: 640.1 Å2
Dissociation area: 181.96 Å2
Dissociation energy (ΔGdiss): -4.5 kcal/mol
Dissociation entropy (TΔSdiss): 1.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170636

Macromolecules

Epithelial discoidin domain-containing receptor 1
Chains: A, B
Length: 337 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08345 (Residues: 601-913; Coverage: 35%)
Gene names: CAK, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Epithelial discoidin domain-containing receptor 1 in PDB entry 5fdx, assembly 2, front view.
Epithelial discoidin domain-containing receptor 1 in PDB entry 5fdx, assembly 2, side view.
Epithelial discoidin domain-containing receptor 1 in PDB entry 5fdx, assembly 2, top view.
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