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Crystal structure of a chimeric c-Src-SH3 domain with the sequence of the RT-loop from the Abl-SH3 domain at pH 5.0

X-ray diffraction
1.65Å resolution
PDB entry 5ec7 coloured by chain, front view.
PDB entry 5ec7 coloured by chain, side view.
PDB entry 5ec7 coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 3619.03 Å2
Buried surface area: 481.39 Å2
Dissociation area: 113.26 Å2
Dissociation energy (ΔGdiss): -3.73 kcal/mol
Dissociation entropy (TΔSdiss): 1.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629
Assembly 2 (preferred)
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 3466.64 Å2
Buried surface area: 267.15 Å2
Dissociation area: 133.57 Å2
Dissociation energy (ΔGdiss): -4.07 kcal/mol
Dissociation entropy (TΔSdiss): 1.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629
Assembly 3
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 3427.45 Å2
Buried surface area: 209.53 Å2
Dissociation area: 104.77 Å2
Dissociation energy (ΔGdiss): -3.33 kcal/mol
Dissociation entropy (TΔSdiss): 1.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629

Macromolecules

Proto-oncogene tyrosine-protein kinase Src
Chains: A, B, C
Length: 57 amino acids
Theoretical weight: 6.38 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 85-140; Coverage: 11%)
Gene name: SRC
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
Proto-oncogene tyrosine-protein kinase Src in PDB entry 5ec7, assembly 2, front view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 5ec7, assembly 2, side view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 5ec7, assembly 2, top view.
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