5di8

X-ray diffraction
1.9Å resolution

Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 25.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 104-330; Coverage: 69%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1 Chain: B
Molecule details ›
Chain: B
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 104-330; Coverage: 69%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Fc-III peptide Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.53 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 60.297Å b: 66.835Å c: 79.214Å
α: 90° β: 104.97° γ: 90°
R-values:
R R work R free
0.227 0.224 0.275
Expression systems:
  • Homo sapiens
  • Not provided