PDB 5byy biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Mitogen-activated protein kinase 7
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Multimeric state: monomeric

Accessible surface area: 16764.07 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-171583

$Monomeric assembly 1 of PDB entry 5byy coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 7;</li> <li class='image_legend_li'>1 copy of 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5byy coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 7;</li> <li class='image_legend_li'>1 copy of 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5byy coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 7;</li> <li class='image_legend_li'>1 copy of 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Mitogen-activated protein kinase 7

Chain: A
Length: 346 amino acids
Theoretical weight: 39.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Best match: Q13164 (Residues: 49-394)

Gene names: BMK1, ERK5, MAPK7, PRKM7

Mitogen-activated protein kinase 7 in PDB entry 5byy, assembly 1, front view.

Mitogen-activated protein kinase 7 in PDB entry 5byy, assembly 1, side view.

Mitogen-activated protein kinase 7 in PDB entry 5byy, assembly 1, top view.

FASTA Sequence


    >pdb|5byy|A

FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREG

Molecule details ›

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Protein Data Bank in Europe

ERK5 IN COMPLEX WITH SMALL MOLECULE

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Assembly 1 (preferred)

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PDBe › 5byy › Structure analysis

ERK5 IN COMPLEX WITH SMALL MOLECULE

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Assemblies

Assembly 1 (preferred)

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5byy › Structure analysis