› › Structure analysis

PKA in complex with a halogenated phthalazinone fragment compound.

X-ray diffraction
1.89Å resolution
PDB entry 5bx6 coloured by chain, front view.
PDB entry 5bx6 coloured by chain, side view.
PDB entry 5bx6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase inhibitor alpha and cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 16735.41 Å2
Buried surface area: 3097.01 Å2
Dissociation area: 1,003.57 Å2
Dissociation energy (ΔGdiss): 3.91 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148114

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 351 amino acids
Theoretical weight: 40.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: P17612 (Residues: 1-351)
Gene names: PKACA, PRKACA
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5bx6, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5bx6, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5bx6, assembly 1, top view.
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cAMP-dependent protein kinase inhibitor alpha
Chain: B
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Best match: P61925 (Residues: 6-25)
Gene names: PKIA, PRKACN1
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5bx6, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5bx6, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5bx6, assembly 1, top view.
Molecule details ›

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