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Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.

Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI
Nat Struct Mol Biol 22 788-94 (2015)
Related entries: 5aca, 5d8a, 5ddj

Cited: 59 times
EuropePMC logo PMID: 26389739

Abstract

Virus capsids are primed for disassembly, yet capsid integrity is key to generating a protective immune response. Foot-and-mouth disease virus (FMDV) capsids comprise identical pentameric protein subunits held together by tenuous noncovalent interactions and are often unstable. Chemically inactivated or recombinant empty capsids, which could form the basis of future vaccines, are even less stable than live virus. Here we devised a computational method to assess the relative stability of protein-protein interfaces and used it to design improved candidate vaccines for two poorly stable, but globally important, serotypes of FMDV: O and SAT2. We used a restrained molecular dynamics strategy to rank mutations predicted to strengthen the pentamer interfaces and applied the results to produce stabilized capsids. Structural analyses and stability assays confirmed the predictions, and vaccinated animals generated improved neutralizing-antibody responses to stabilized particles compared to parental viruses and wild-type capsids.

Articles - 5ac9 mentioned but not cited (4)

  1. New tools for the analysis and validation of cryo-EM maps and atomic models. Afonine PV, Klaholz BP, Moriarty NW, Poon BK, Sobolev OV, Terwilliger TC, Adams PD, Urzhumtsev A. Acta Crystallogr D Struct Biol 74 814-840 (2018)
  2. Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI. Nat Struct Mol Biol 22 788-794 (2015)
  3. Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI. Nat Commun 8 15408 (2017)
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Reviews citing this publication (11)

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