› 5y95

Solution NMR

Haddock model of mSIN3B PAH1 domain

Released:
DOI: 10.2210/pdb5y95/pdb
PDB entry 5y95 coloured by chain, ensemble of 10 models, front view.
PDB entry 5y95 coloured by chain, ensemble of 10 models, side view.
PDB entry 5y95 coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models.
Ueda H, Kurita JI, Neyama H, Hirao Y, Kouji H, Mishina T, Kasai M, Nakano H, Yoshimori A, Nishimura Y
Bioorg Med Chem Lett 27 4705-4709 (2017)
PMID: 28927787

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paired amphipathic helix protein Sin3b Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q62141 (Residues: 32-98; Coverage: 6%)
Gene names: Kiaa0700, Sin3b
Sequence domains: Paired amphipathic helix repeat
Structure domains: Paired amphipathic helix

Ligands and Environments

1 bound ligand:
Ligand 8TL 1 x 8TL
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

NRSF and Its Epigenetic Effectors: New Treatments for Neurological Disease.
Thompson et al. (2018)
3 more

1 mention without citation

Visualized and Quantitative Conformational Analysis of Peptidomimetics.
Takashima et al. (2021)