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Structure of apo human ALDH7A1 in space group P4212

X-ray diffraction
1.9Å resolution
PDB entry 4zvx coloured by chain, front view.
PDB entry 4zvx coloured by chain, side view.
PDB entry 4zvx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-aminoadipic semialdehyde dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 65718.26 Å2
Buried surface area: 11843.8 Å2
Dissociation area: 2,526.62 Å2
Dissociation energy (ΔGdiss): 32.79 kcal/mol
Dissociation entropy (TΔSdiss): 16.15 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-155949

Macromolecules

Alpha-aminoadipic semialdehyde dehydrogenase
Chains: A, B
Length: 513 amino acids
Theoretical weight: 55.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49419 (Residues: 29-539; Coverage: 95%)
Gene names: ALDH7A1, ATQ1
Pfam: Aldehyde dehydrogenase family
InterPro:
CATH:
Alpha-aminoadipic semialdehyde dehydrogenase in PDB entry 4zvx, assembly 1, front view.
Alpha-aminoadipic semialdehyde dehydrogenase in PDB entry 4zvx, assembly 1, side view.
Alpha-aminoadipic semialdehyde dehydrogenase in PDB entry 4zvx, assembly 1, top view.
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