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THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR

X-ray diffraction
2.1Å resolution
PDB entry 4z9l coloured by chain, front view.
PDB entry 4z9l coloured by chain, side view.
PDB entry 4z9l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 10
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Multimeric state: monomeric
Accessible surface area: 15601.3 Å2
Buried surface area: 1752.57 Å2
Dissociation area: 379.69 Å2
Dissociation energy (ΔGdiss): 2.97 kcal/mol
Dissociation entropy (TΔSdiss): 5.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156874

Macromolecules

Mitogen-activated protein kinase 10
Chain: A
Length: 364 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53779 (Residues: 40-401; Coverage: 78%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 10 in PDB entry 4z9l, assembly 1, front view.
Mitogen-activated protein kinase 10 in PDB entry 4z9l, assembly 1, side view.
Mitogen-activated protein kinase 10 in PDB entry 4z9l, assembly 1, top view.
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