Function and Biology

Human FAN1 nuclease

Source organism: Homo sapiens
Biochemical function: hydrolase activity, acting on ester bonds
Biological process: interstrand cross-link repair
Cellular component: not assigned

EC 3.1.4.1: Phosphodiesterase I

Reaction catalysed:
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Systematic name:
Oligonucleotide 5'-nucleotidohydrolase
Alternative Name(s):
  • 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
  • 5'-NPDase
  • 5'-PDE
  • 5'-PDase
  • 5'-exonuclease
  • 5'-nucleotide phosphodiesterase
  • 5'-phosphodiesterase
  • 5'NPDE
  • Alkaline phosphodiesterase
  • Exonuclease I
  • Nucleotide pyrophosphatase/phosphodiesterase I
  • Oligonucleate 5'-nucleotidohydrolase
  • Orthophosphoric diester phosphohydrolase
  • PDE I
  • Phosphodiesterase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08774
Domain description: VRR-NUC domain
Occurring in:
  1. Fanconi-associated nuclease 1
The deposited structure of PDB entry 4rid contains 2 copies of Pfam domain PF08774 (VRR-NUC domain) in Fanconi-associated nuclease 1. Showing 1 copy in chain B.

PF21170
Domain description: Fanconi-associated nuclease 1, TPR domain
Occurring in:
  1. Fanconi-associated nuclease 1
The deposited structure of PDB entry 4rid contains 2 copies of Pfam domain PF21170 (Fanconi-associated nuclease 1, TPR domain) in Fanconi-associated nuclease 1. Showing 1 copy in chain B.

PF21169
Domain description: Fanconi-associated nuclease 1, SAP subdomain
Occurring in:
  1. Fanconi-associated nuclease 1
The deposited structure of PDB entry 4rid contains 2 copies of Pfam domain PF21169 (Fanconi-associated nuclease 1, SAP subdomain) in Fanconi-associated nuclease 1. Showing 1 copy in chain B.

PF21315
Domain description: FAN1, HTH domain
Occurring in:
  1. Fanconi-associated nuclease 1
The deposited structure of PDB entry 4rid contains 2 copies of Pfam domain PF21315 (FAN1, HTH domain) in Fanconi-associated nuclease 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR014883
Domain description: VRR-NUC domain
Occurring in:
  1. Fanconi-associated nuclease 1
IPR011856
Domain description: tRNA endonuclease-like domain superfamily
Occurring in:
  1. Fanconi-associated nuclease 1
IPR033315
Domain description: Fanconi-associated nuclease 1-like
Occurring in:
  1. Fanconi-associated nuclease 1