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Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)

X-ray diffraction
1.5Å resolution
PDB entry 4rbw coloured by chain, front view.
PDB entry 4rbw coloured by chain, side view.
PDB entry 4rbw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: HD5(63-94)
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Multimeric state: homo dimer
Accessible surface area: 4719.68 Å2
Buried surface area: 1612.12 Å2
Dissociation area: 416.64 Å2
Dissociation energy (ΔGdiss): 0.93 kcal/mol
Dissociation entropy (TΔSdiss): 8.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-169582
Assembly 2 (preferred)
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Assembly Name: HD5(63-94)
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Multimeric state: homo dimer
Accessible surface area: 4714.75 Å2
Buried surface area: 1799.4 Å2
Dissociation area: 534.12 Å2
Dissociation energy (ΔGdiss): 9.99 kcal/mol
Dissociation entropy (TΔSdiss): 8.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169582

Macromolecules

HD5(63-94)
Chains: A, B, C, D
Length: 32 amino acids
Theoretical weight: 3.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Best match: Q01523 (Residues: 63-94)
Gene names: DEF5, DEFA5
HD5(63-94) in PDB entry 4rbw, assembly 2, front view.
HD5(63-94) in PDB entry 4rbw, assembly 2, side view.
HD5(63-94) in PDB entry 4rbw, assembly 2, top view.
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