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Crystal Structure of STK25-MO25 Complex

X-ray diffraction
3.583Å resolution
PDB entry 4nzw coloured by chain, front view.
PDB entry 4nzw coloured by chain, side view.
PDB entry 4nzw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium-binding protein 39 and Serine/threonine-protein kinase 25
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Multimeric state: hetero dimer
Accessible surface area: 27942.31 Å2
Buried surface area: 2834.66 Å2
Dissociation area: 978.92 Å2
Dissociation energy (ΔGdiss): 1.83 kcal/mol
Dissociation entropy (TΔSdiss): 13.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126325

Macromolecules

Calcium-binding protein 39
Chain: A
Length: 331 amino acids
Theoretical weight: 38.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: Q9Y376 (Residues: 8-334)
Gene names: CAB39, CGI-66, MO25
Calcium-binding protein 39 in PDB entry 4nzw, assembly 1, front view.
Calcium-binding protein 39 in PDB entry 4nzw, assembly 1, side view.
Calcium-binding protein 39 in PDB entry 4nzw, assembly 1, top view.
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Serine/threonine-protein kinase 25
Chain: B
Length: 295 amino acids
Theoretical weight: 33.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: O00506 (Residues: 1-293)
Gene names: SOK1, STK25, YSK1
Serine/threonine-protein kinase 25 in PDB entry 4nzw, assembly 1, front view.
Serine/threonine-protein kinase 25 in PDB entry 4nzw, assembly 1, side view.
Serine/threonine-protein kinase 25 in PDB entry 4nzw, assembly 1, top view.
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