EC 7.2.2.10: P-type Ca(2+) transporter
Reaction catalysed:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, Ca(2+)-transporting)
Alternative Name(s):
- Ca(2+)-pumping ATPase
- Ca(2+)-transporting ATPase
- Calcium pump
- Calcium-translocating P-type ATPase
- Plasma membrane Ca-ATPase
- Sarco(endo)plasmic reticulum Ca(2+)-ATPase
- Sarcoplasmic reticulum ATPase
GO terms
Biochemical function:
Biological process:
- calcium ion import into sarcoplasmic reticulum
- positive regulation of calcium ion import into sarcoplasmic reticulum
- positive regulation of ATPase-coupled calcium transmembrane transporter activity
- positive regulation of cardiac muscle cell contraction
- calcium ion transmembrane transport
- positive regulation of fast-twitch skeletal muscle fiber contraction
- intracellular calcium ion homeostasis
- calcium ion transport
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.40.50.1000
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
HAD superfamily/HAD-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4nab</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.1000 (Rossmann fold)</span> in <span class='highlight'>Sarcoplasmic/endoplasmic reticulum calcium ATPase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4nab contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4nab_1_A_CATH_3.40.50.1000_image-200x200.png)
1.20.1110.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Calcium-transporting ATPase, transmembrane domain
Homology:
Calcium-transporting ATPase, transmembrane domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4nab</span> contains 1 copy of CATH domain <span class='highlight'>1.20.1110.10 (Calcium-transporting ATPase, transmembrane domain)</span> in <span class='highlight'>Sarcoplasmic/endoplasmic reticulum calcium ATPase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4nab contains 1 copy of CATH domain 1.20.1110.10 (Calcium-transporting ATPase, transmembrane domain) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4nab_1_A_CATH_1.20.1110.10_image-200x200.png)