Domain

P-type ATPase, cytoplasmic domain N (IPR023299)

Short name: ATPase_P-typ_cyto_domN

Domain relationships

  • HAD-like domain (IPR023214)
    • P-type ATPase, cytoplasmic domain N (IPR023299)

Description

P-ATPases (also known as E1-E2 ATPases) (EC:3.6.3.-) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [PMID: 9419228]. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H+, Na+, K+, Mg2+, Ca2+, Ag+ and Ag2+, Zn2+, Co2+, Pb2+, Ni2+, Cd2+, Cu+ and Cu2+. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.

This entry represents the cytoplasmic domain N found in P-type ATPases. The cytoplasmic loops of the P-type ATPases form three separate modules, commonly named the A, P and N-domains [PMID: 15448704]. The N-domain comprises the nucleotide binding site [PMID: 15364580]. This domain forms a seven-stranded antiparallel beta-sheet with two additional beta-strands forming a hairpin and five alpha-helices [PMID: 14499619].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0000166 nucleotide binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY