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The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252

X-ray diffraction
1.14Å resolution
PDB entry 4lwu coloured by chain, front view.
PDB entry 4lwu coloured by chain, side view.
PDB entry 4lwu coloured by chain, top view.
Source organism: Xenopus laevis
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase Mdm2
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Multimeric state: monomeric
Accessible surface area: 5542.62 Å2
Buried surface area: 208.81 Å2
Dissociation area: 104.4 Å2
Dissociation energy (ΔGdiss): 18.8 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157449

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chain: A
Length: 85 amino acids
Theoretical weight: 9.83 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P56273 (Residues: 21-105; Coverage: 18%)
Gene name: mdm2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4lwu, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4lwu, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4lwu, assembly 1, top view.
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