PDB 4iti biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

Download 3D Visualisation

Assembly Name: Receptor-interacting serine/threonine-protein kinase 1
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 13235.02 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-171747

$Monomeric assembly 1 of PDB entry 4iti coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4iti coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4iti coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

Assembly 2

Download 3D Visualisation

Assembly Name: Receptor-interacting serine/threonine-protein kinase 1
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 13193.82 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-171747

$Monomeric assembly 2 of PDB entry 4iti coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4iti coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4iti coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Receptor-interacting serine/threonine-protein kinase 1;</li> <li class='image_legend_li'>1 copy of 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone.</li></ul>}$

Macromolecules

Receptor-interacting serine/threonine-protein kinase 1

Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: Q13546 (Residues: 1-294; Coverage: 44%)

Gene names: RIP, RIP1, RIPK1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Serine/threonine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Receptor-interacting serine/threonine-protein kinase 1 in PDB entry 4iti, assembly 1, front view.

Receptor-interacting serine/threonine-protein kinase 1 in PDB entry 4iti, assembly 1, side view.

Receptor-interacting serine/threonine-protein kinase 1 in PDB entry 4iti, assembly 1, top view.

FASTA Sequence


    >pdb|4iti|A B

MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE

PDBe-KB: UniProt Coverage View: Q13546

Molecule details ›

Download

FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST Q13546 (UniProt)

Protein Data Bank in Europe

Crystal structure of RIP1 kinase in complex with necrostatin-3 analog

Quick links

Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

Search similar proteins

Quick links

PDBe › 4iti › Structure analysis

Crystal structure of RIP1 kinase in complex with necrostatin-3 analog

Quick links

Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

Search similar proteins

Quick links

4iti › Structure analysis