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Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164A Mutant

Source organism: Pasteurella multocida subsp. gallicida P1059
Biochemical function: lyase activity
Biological process: N-acetylneuraminate catabolic process
Cellular component: cytosol

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EC 4.1.3.3: N-acetylneuraminate lyase

Reaction catalysed:
Aceneneuramate = N-acetyl-D-mannosamine + pyruvate
Systematic name:
Aceneneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Alternative Name(s):
  • Acetylneuraminate lyase
  • Acetylneuraminate pyruvate-lyase
  • N-acetylneuraminate aldolase
  • N-acetylneuraminate pyruvate-lyase
  • N-acetylneuraminic acid aldolase
  • N-acetylneuraminic acid lyase
  • N-acetylneuraminic aldolase
  • N-acetylneuraminic lyase
  • NALase
  • NANA lyase
  • NPL
  • Neuraminate aldolase
  • Neuraminic acid aldolase
  • Neuraminic aldolase
  • Sialate lyase
  • Sialic acid aldolase
  • Sialic aldolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00701
Domain description: Dihydrodipicolinate synthetase family
Occurring in:
  1. N-acetylneuraminate lyase
The deposited structure of PDB entry 4ime contains 8 copies of Pfam domain PF00701 (Dihydrodipicolinate synthetase family) in N-acetylneuraminate lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002220
Domain description: DapA-like
Occurring in:
  1. N-acetylneuraminate lyase
IPR005264
Domain description: N-acetylneuraminate lyase
Occurring in:
  1. N-acetylneuraminate lyase
IPR020624
Domain description: Schiff base-forming aldolase, conserved site
Occurring in:
  1. N-acetylneuraminate lyase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. N-acetylneuraminate lyase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. N-acetylneuraminate lyase
The deposited structure of PDB entry 4ime contains 8 copies of CATH domain 3.20.20.70 (TIM Barrel) in N-acetylneuraminate lyase. Showing 1 copy in chain A.

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