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The Crystal Structure of a Human MitoNEET mutant with Asp 67 replaced by a Gly

Source organism: Homo sapiens
Biochemical function: 2 iron, 2 sulfur cluster binding
Biological process: regulation of autophagy
Cellular component: intracellular membrane-bounded organelle

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EC 2.6.1.3: Cysteine transaminase

Reaction catalysed:
L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate
Systematic name:
L-cysteine:2-oxoglutarate aminotransferase
Alternative Name(s):
  • CGT
  • Cysteine aminotransferase
  • L-cysteine aminotransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF09360
Domain description: Iron-binding zinc finger CDGSH type
Occurring in:
  1. CDGSH iron-sulfur domain-containing protein 1
The deposited structure of PDB entry 4f1e contains 18 copies of Pfam domain PF09360 (Iron-binding zinc finger CDGSH type) in CDGSH iron-sulfur domain-containing protein 1. Showing 1 copy in chain J.

InterPro InterPro annotations
IPR018967
Domain description: Iron-binding zinc finger, CDGSH type
Occurring in:
  1. CDGSH iron-sulfur domain-containing protein 1
IPR042216
Domain description: MitoNEET, CDGSH iron-sulfur domain
Occurring in:
  1. CDGSH iron-sulfur domain-containing protein 1
IPR045131
Domain description: CDGSH iron-sulfur domain-containing protein 1/2
Occurring in:
  1. CDGSH iron-sulfur domain-containing protein 1

Structure domain

CATH CATH domain
3.40.5.90
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Ribosomal Protein L9; domain 1
Homology: CDGSH iron-sulfur domain, mitoNEET-type
Occurring in:
  1. CDGSH iron-sulfur domain-containing protein 1
The deposited structure of PDB entry 4f1e contains 18 copies of CATH domain 3.40.5.90 (Ribosomal Protein L9; domain 1) in CDGSH iron-sulfur domain-containing protein 1. Showing 1 copy in chain C.

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