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Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide

X-ray diffraction
1.66Å resolution
PDB entry 4ia9 coloured by chain, front view.
PDB entry 4ia9 coloured by chain, side view.
PDB entry 4ia9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5
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Multimeric state: monomeric
Accessible surface area: 11422.37 Å2
Buried surface area: 406.89 Å2
Dissociation area: 108.08 Å2
Dissociation energy (ΔGdiss): -2.21 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158474

Macromolecules

WD repeat-containing protein 5
Chain: A
Length: 312 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 4ia9, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 4ia9, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 4ia9, assembly 1, top view.
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