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Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A

Source organism: Gallus gallus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: cytoskeleton

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EC 2.7.10.2: Non-specific protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Alternative Name(s):
  • ABL
  • ABL1
  • ABL2
  • ABLL
  • ACK1
  • ACK2
  • AGMX1
  • ARG
  • ATK
  • ATP:protein-tyrosine O-phosphotransferase
  • BLK
  • BMX
  • BRK
  • BTK
  • BTKL
  • Bmk
  • Bruton's tyrosine kinase
  • Bsk
  • CAKb
  • CHK
  • CSK
  • CTK
  • CYL
  • Cdgip
  • Cytoplasmic protein tyrosine kinase
  • EMT
  • ETK
  • FAK
  • FAK2
  • FER
  • FES
  • FGR
  • FPS
  • FRK
  • FYN
  • Fadk
  • Fert1/2
  • Focal adhesion kinase
  • HCK
  • HCTK
  • HYL
  • IMD1
  • ITK
  • IYK
  • JAK1
  • JAK2
  • JAK3
  • JTK1
  • JTK9
  • Janus kinase 1
  • Janus kinase 2
  • Janus kinase 3
  • L-JAK
  • LCK
  • LSK
  • LYN
  • MATK
  • Ntk
  • P60c-src protein tyrosine kinase
  • PKB
  • PSCTK
  • PSCTK1
  • PSCTK2
  • PSCTK4
  • PSCTK5
  • PTK2
  • PTK2B
  • PTK6
  • PYK2
  • Protein-tyrosine kinase
  • RAFTK
  • RAK
  • Rlk
  • SLK
  • SRC
  • SRC2
  • SRK
  • SRM
  • SRMS
  • STD
  • SYK
  • SYN
  • Sik
  • TEC
  • TNK1
  • TXK
  • TYK2
  • TYK3
  • Tck
  • Tsk
  • YES1
  • YK2
  • ZAP70

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF21477
Domain description: FAK1/PYK2, FERM domain C-lobe
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of Pfam domain PF21477 (FAK1/PYK2, FERM domain C-lobe) in Focal adhesion kinase 1. Showing 1 copy in chain A.

PF00373
Domain description: FERM central domain
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of Pfam domain PF00373 (FERM central domain) in Focal adhesion kinase 1. Showing 1 copy in chain A.

PF18038
Domain description: FERM N-terminal domain
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of Pfam domain PF18038 (FERM N-terminal domain) in Focal adhesion kinase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019748
Domain description: FERM central domain
Occurring in:
  1. Focal adhesion kinase 1
IPR041784
Domain description: FAK1/PYK2, FERM domain C-lobe
Occurring in:
  1. Focal adhesion kinase 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Focal adhesion kinase 1
IPR035963
Domain description: FERM superfamily, second domain
Occurring in:
  1. Focal adhesion kinase 1
IPR014352
Domain description: FERM/acyl-CoA-binding protein superfamily
Occurring in:
  1. Focal adhesion kinase 1
IPR041390
Domain description: Focal adhesion kinase, N-terminal
Occurring in:
  1. Focal adhesion kinase 1
IPR000299
Domain description: FERM domain
Occurring in:
  1. Focal adhesion kinase 1
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Focal adhesion kinase 1
IPR019749
Domain description: Band 4.1 domain
Occurring in:
  1. Focal adhesion kinase 1

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Focal adhesion kinase 1. Showing 1 copy in chain A.
1.20.80.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Acyl-CoA Binding Protein
Homology: Acyl-CoA Binding Protein
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of CATH domain 1.20.80.10 (Acyl-CoA Binding Protein) in Focal adhesion kinase 1. Showing 1 copy in chain A.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Focal adhesion kinase 1
The deposited structure of PDB entry 3zdt contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Focal adhesion kinase 1. Showing 1 copy in chain A.

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