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Crystal structure of PAN-Rpt5C chimera

X-ray diffraction
2.6Å resolution
PDB entry 3whk coloured by chain, front view.
PDB entry 3whk coloured by chain, side view.
PDB entry 3whk coloured by chain, top view.
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12621.64 Å2
Buried surface area: 778.64 Å2
Dissociation area: 389.32 Å2
Dissociation energy (ΔGdiss): 4.55 kcal/mol
Dissociation entropy (TΔSdiss): 5.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 2
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12315.89 Å2
Buried surface area: 765.97 Å2
Dissociation area: 382.99 Å2
Dissociation energy (ΔGdiss): 3.81 kcal/mol
Dissociation entropy (TΔSdiss): 5.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 3
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12413.73 Å2
Buried surface area: 767.6 Å2
Dissociation area: 383.8 Å2
Dissociation energy (ΔGdiss): 4.98 kcal/mol
Dissociation entropy (TΔSdiss): 5.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 4
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12282.71 Å2
Buried surface area: 766.69 Å2
Dissociation area: 383.34 Å2
Dissociation energy (ΔGdiss): 4.42 kcal/mol
Dissociation entropy (TΔSdiss): 5.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 5
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12608.07 Å2
Buried surface area: 762.93 Å2
Dissociation area: 381.47 Å2
Dissociation energy (ΔGdiss): 4.1 kcal/mol
Dissociation entropy (TΔSdiss): 5.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 6
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12316.8 Å2
Buried surface area: 773.85 Å2
Dissociation area: 386.92 Å2
Dissociation energy (ΔGdiss): 4.98 kcal/mol
Dissociation entropy (TΔSdiss): 5.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 7
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12453.27 Å2
Buried surface area: 775.07 Å2
Dissociation area: 387.54 Å2
Dissociation energy (ΔGdiss): 4.87 kcal/mol
Dissociation entropy (TΔSdiss): 5.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572
Assembly 8
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Assembly Name: 26S proteasome regulatory subunit 6A, Proteasome-activating nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12344.38 Å2
Buried surface area: 767.19 Å2
Dissociation area: 383.6 Å2
Dissociation energy (ΔGdiss): 5.25 kcal/mol
Dissociation entropy (TΔSdiss): 5.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152572

Macromolecules

26S proteasome regulatory subunit 6A; Proteasome-activating nucleotidase
Chains: A, B, C, D, E, F, G, H
Length: 270 amino acids
Theoretical weight: 30.02 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q8U4H3 (Residues: 125-309; Coverage: 47%)
  • Canonical: P33297 (Residues: 356-434; Coverage: 18%)
    • nullnull
Gene names: O3258, PF0115, RPT5, YOR117W, YOR3258W, YTA1, pan
Pfam:
InterPro:
CATH:
26S proteasome regulatory subunit 6A in PDB entry 3whk, assembly 1, front view.
26S proteasome regulatory subunit 6A in PDB entry 3whk, assembly 1, side view.
26S proteasome regulatory subunit 6A in PDB entry 3whk, assembly 1, top view.
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