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Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447

X-ray diffraction
2.9Å resolution
PDB entry 3twj coloured by chain, front view.
PDB entry 3twj coloured by chain, side view.
PDB entry 3twj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Rho-associated protein kinase 1
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Multimeric state: homo dimer
Accessible surface area: 36842.81 Å2
Buried surface area: 4118.1 Å2
Dissociation area: 1,841.32 Å2
Dissociation energy (ΔGdiss): 21.51 kcal/mol
Dissociation entropy (TΔSdiss): 14.38 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171700
Assembly 2 (preferred)
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Assembly Name: Rho-associated protein kinase 1
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Multimeric state: homo dimer
Accessible surface area: 36665.99 Å2
Buried surface area: 3579.77 Å2
Dissociation area: 1,677.47 Å2
Dissociation energy (ΔGdiss): 20.63 kcal/mol
Dissociation entropy (TΔSdiss): 14.34 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171700

Macromolecules

Rho-associated protein kinase 1
Chains: A, B, C, D
Length: 410 amino acids
Theoretical weight: 47.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Gene name: ROCK1
Rho-associated protein kinase 1 in PDB entry 3twj, assembly 2, front view.
Rho-associated protein kinase 1 in PDB entry 3twj, assembly 2, side view.
Rho-associated protein kinase 1 in PDB entry 3twj, assembly 2, top view.
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