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Crystal structure of Chk1 in complex with inhibitor S01

X-ray diffraction
1.79Å resolution
PDB entry 3tkh coloured by chain, front view.
PDB entry 3tkh coloured by chain, side view.
PDB entry 3tkh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase Chk1
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Multimeric state: monomeric
Accessible surface area: 14015.93 Å2
Buried surface area: 206.94 Å2
Dissociation area: 103.47 Å2
Dissociation energy (ΔGdiss): 17.65 kcal/mol
Dissociation entropy (TΔSdiss): 0.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127093

Macromolecules

Serine/threonine-protein kinase Chk1
Chain: A
Length: 323 amino acids
Theoretical weight: 36.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: O14757 (Residues: 1-307)
Gene names: CHEK1, CHK1
Serine/threonine-protein kinase Chk1 in PDB entry 3tkh, assembly 1, front view.
Serine/threonine-protein kinase Chk1 in PDB entry 3tkh, assembly 1, side view.
Serine/threonine-protein kinase Chk1 in PDB entry 3tkh, assembly 1, top view.
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