3t7c

X-ray diffraction
1.95Å resolution

Crystal structure of carveol dehydrogenase from Mycobacterium avium bound to NAD

Released:

Function and Biology Details

Reaction catalysed:
(+)-trans-carveol + NAD(+) = (+)-(S)-carvone + NADH
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carveol dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 299 amino acids
Theoretical weight: 32.21 KDa
Source organism: Mycobacterium avium 104
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0H2ZWY3 (Residues: 1-278; Coverage: 100%)
Gene name: MAV_1393
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 69.55Å b: 108.41Å c: 148.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.195
Expression system: Escherichia coli