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IspH:HMBPP complex structure of E126Q mutant

X-ray diffraction
1.4Å resolution
PDB entry 3szu coloured by chain, front view.
PDB entry 3szu coloured by chain, side view.
PDB entry 3szu coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
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Multimeric state: monomeric
Accessible surface area: 14251.32 Å2
Buried surface area: 374.07 Å2
Dissociation area: 187.04 Å2
Dissociation energy (ΔGdiss): 16.1 kcal/mol
Dissociation entropy (TΔSdiss): 3.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158657
Assembly 2
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Assembly Name: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
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Multimeric state: monomeric
Accessible surface area: 14459.14 Å2
Buried surface area: 374.66 Å2
Dissociation area: 187.33 Å2
Dissociation energy (ΔGdiss): 16.13 kcal/mol
Dissociation entropy (TΔSdiss): 3.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158657

Macromolecules

4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Chains: A, B
Length: 328 amino acids
Theoretical weight: 36.22 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P62623 (Residues: 1-316; Coverage: 100%)
Gene names: JW0027, b0029, ispH, lytB, yaaE
Pfam: LytB protein
InterPro: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
CATH:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase in PDB entry 3szu, assembly 1, front view.
4-hydroxy-3-methylbut-2-enyl diphosphate reductase in PDB entry 3szu, assembly 1, side view.
4-hydroxy-3-methylbut-2-enyl diphosphate reductase in PDB entry 3szu, assembly 1, top view.
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