Structure analysis

Crystal structure of human CD38 in complex with compound CZ-46

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 13172.11 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151306
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 13029.37 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151306

Macromolecules

Chains: A, B
Length: 254 amino acids
Theoretical weight: 29.54 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 45-296; Coverage: 84%)
Gene name: CD38
Pfam: ADP-ribosyl cyclase
InterPro: ADP-ribosyl cyclase (CD38/157)
CATH:

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