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Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279

X-ray diffraction
1.75Å resolution
PDB entry 3r0t coloured by chain, front view.
PDB entry 3r0t coloured by chain, side view.
PDB entry 3r0t coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Casein kinase II subunit alpha
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Multimeric state: monomeric
Accessible surface area: 14857.62 Å2
Buried surface area: 3045.9 Å2
Dissociation area: 106.12 Å2
Dissociation energy (ΔGdiss): -3.98 kcal/mol
Dissociation entropy (TΔSdiss): -0.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159383

Macromolecules

Casein kinase II subunit alpha
Chain: A
Length: 337 amino acids
Theoretical weight: 40.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-337; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Pfam: Protein kinase domain
InterPro:
CATH:
Casein kinase II subunit alpha in PDB entry 3r0t, assembly 1, front view.
Casein kinase II subunit alpha in PDB entry 3r0t, assembly 1, side view.
Casein kinase II subunit alpha in PDB entry 3r0t, assembly 1, top view.
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