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Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1

X-ray diffraction
2Å resolution
PDB entry 3i65 coloured by chain, front view.
PDB entry 3i65 coloured by chain, side view.
PDB entry 3i65 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
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Multimeric state: monomeric
Accessible surface area: 16116.12 Å2
Buried surface area: 1478.86 Å2
Dissociation area: 130.81 Å2
Dissociation energy (ΔGdiss): -6.83 kcal/mol
Dissociation entropy (TΔSdiss): 3.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170607

Macromolecules

Dihydroorotate dehydrogenase (quinone), mitochondrial
Chain: A
Length: 415 amino acids
Theoretical weight: 46.65 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
Gene name: PFF0160c
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3i65, assembly 1, front view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3i65, assembly 1, side view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3i65, assembly 1, top view.
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