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Crystal structure of the CERT START domain in complex with HPA-16

X-ray diffraction
2.4Å resolution
PDB entry 3h3t coloured by chain, front view.
PDB entry 3h3t coloured by chain, side view.
PDB entry 3h3t coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ceramide transfer protein
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Multimeric state: monomeric
Accessible surface area: 12258.12 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195280
Assembly 2
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Assembly Name: Ceramide transfer protein
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Multimeric state: monomeric
Accessible surface area: 12046.39 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195280

Macromolecules

Ceramide transfer protein
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5P4 (Residues: 347-624; Coverage: 40%)
Gene names: CERT, CERT1, COL4A3BP, STARD11
Pfam: START domain
InterPro:
CATH: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4
Ceramide transfer protein in PDB entry 3h3t, assembly 1, front view.
Ceramide transfer protein in PDB entry 3h3t, assembly 1, side view.
Ceramide transfer protein in PDB entry 3h3t, assembly 1, top view.
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