› 3g6j

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-208328 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C3 beta chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 644 amino acids
Theoretical weight: 71.32 KDa
Source organism: Homo sapiens
Gene names: C3, CPAMD1
Complement C3b alpha' chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
Gene names: C3, CPAMD1
Fab light chain Chains: E, G
Molecule details ›
Chains: E, G
Length: 214 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab heavy chain Chains: F, H
Molecule details ›
Chains: F, H
Length: 226 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 216.436Å b: 180.417Å c: 154.584Å
α: 90° β: 115.73° γ: 90°
R-values:
R R work R free
0.218 0.214 0.282
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Complement, a target for therapy in inflammatory and degenerative diseases.
Morgan et al. (2015)
11 more

3 mentions without citation

Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.
Ricklin D. (2012)
2 more