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C3b in complex with a C3b specific Fab

X-ray diffraction
3.1Å resolution
PDB entry 3g6j coloured by chain, front view.
PDB entry 3g6j coloured by chain, side view.
PDB entry 3g6j coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer (preferred)
hetero dimer
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement C3b complex and antibody
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Multimeric state: hetero tetramer
Accessible surface area: 87631.97 Å2
Buried surface area: 15746.81 Å2
Dissociation area: 1,019.62 Å2
Dissociation energy (ΔGdiss): -5.91 kcal/mol
Dissociation entropy (TΔSdiss): 15.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208328
Assembly 2
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Assembly Name: Complement C3b complex and antibody
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Multimeric state: hetero tetramer
Accessible surface area: 87351.24 Å2
Buried surface area: 15486.12 Å2
Dissociation area: 1,051.75 Å2
Dissociation energy (ΔGdiss): 0.03 kcal/mol
Dissociation entropy (TΔSdiss): 15.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208328
Assembly 3
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19692.19 Å2
Buried surface area: 3740.65 Å2
Dissociation area: 1,870.32 Å2
Dissociation energy (ΔGdiss): 22.84 kcal/mol
Dissociation entropy (TΔSdiss): 13.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-219723
Assembly 4
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19448.03 Å2
Buried surface area: 3668.35 Å2
Dissociation area: 1,834.18 Å2
Dissociation energy (ΔGdiss): 23.35 kcal/mol
Dissociation entropy (TΔSdiss): 13.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-219723
Assembly 5
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Assembly Name: Complement C3b complex
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Multimeric state: hetero dimer
Accessible surface area: 69968.24 Å2
Buried surface area: 9977.7 Å2
Dissociation area: 4,945.03 Å2
Dissociation energy (ΔGdiss): 68.12 kcal/mol
Dissociation entropy (TΔSdiss): 16.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133822
Complex Portal ID: CPX-973
Assembly 6
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Assembly Name: Complement C3b complex
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Multimeric state: hetero dimer
Accessible surface area: 69996.35 Å2
Buried surface area: 9724.63 Å2
Dissociation area: 4,816.99 Å2
Dissociation energy (ΔGdiss): 67.59 kcal/mol
Dissociation entropy (TΔSdiss): 16.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133822
Complex Portal ID: CPX-973

Macromolecules

Complement C3 beta chain
Chains: A, C
Length: 644 amino acids
Theoretical weight: 71.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-666; Coverage: 39%)
Gene names: C3, CPAMD1
Pfam:
InterPro:
CATH:
Complement C3 beta chain in PDB entry 3g6j, assembly 1, front view.
Complement C3 beta chain in PDB entry 3g6j, assembly 1, side view.
Complement C3 beta chain in PDB entry 3g6j, assembly 1, top view.
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Complement C3b alpha' chain
Chains: B, D
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Gene names: C3, CPAMD1
Pfam:
InterPro:
CATH:
Complement C3b alpha' chain in PDB entry 3g6j, assembly 1, front view.
Complement C3b alpha' chain in PDB entry 3g6j, assembly 1, side view.
Complement C3b alpha' chain in PDB entry 3g6j, assembly 1, top view.
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Fab light chain
Chains: E, G
Length: 214 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
Fab light chain in PDB entry 3g6j, assembly 1, front view.
Fab light chain in PDB entry 3g6j, assembly 1, side view.
Fab light chain in PDB entry 3g6j, assembly 1, top view.
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Fab heavy chain
Chains: F, H
Length: 226 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
Fab heavy chain in PDB entry 3g6j, assembly 1, front view.
Fab heavy chain in PDB entry 3g6j, assembly 1, side view.
Fab heavy chain in PDB entry 3g6j, assembly 1, top view.
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