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Crystal structure of Septin 2 in complex with GppNHp and Mg2+

X-ray diffraction
2.9Å resolution
PDB entry 3ftq coloured by chain, front view.
PDB entry 3ftq coloured by chain, side view.
PDB entry 3ftq coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Septin-2
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Multimeric state: monomeric
Accessible surface area: 14257.55 Å2
Buried surface area: 963.99 Å2
Dissociation area: 73.84 Å2
Dissociation energy (ΔGdiss): 11.77 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154507
Assembly 2
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Assembly Name: Septin-2
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Multimeric state: monomeric
Accessible surface area: 13852.26 Å2
Buried surface area: 972.37 Å2
Dissociation area: 75.2 Å2
Dissociation energy (ΔGdiss): 11.98 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154507
Assembly 3
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Assembly Name: Septin-2
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Multimeric state: monomeric
Accessible surface area: 13843.62 Å2
Buried surface area: 975.11 Å2
Dissociation area: 72.42 Å2
Dissociation energy (ΔGdiss): 11.74 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154507
Assembly 4
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Assembly Name: Septin-2
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Multimeric state: monomeric
Accessible surface area: 13880.5 Å2
Buried surface area: 958.91 Å2
Dissociation area: 76.07 Å2
Dissociation energy (ΔGdiss): 11.83 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154507
Assembly 5
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Assembly Name: Septin-2
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Multimeric state: homo dimer
Accessible surface area: 25297.99 Å2
Buried surface area: 4748.19 Å2
Dissociation area: 1,412.74 Å2
Dissociation energy (ΔGdiss): 0.22 kcal/mol
Dissociation entropy (TΔSdiss): 13.34 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154508
Assembly 6
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Assembly Name: Septin-2
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Multimeric state: homo dimer
Accessible surface area: 25210.12 Å2
Buried surface area: 4448.02 Å2
Dissociation area: 1,266.03 Å2
Dissociation energy (ΔGdiss): 1.16 kcal/mol
Dissociation entropy (TΔSdiss): 13.24 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154508

Macromolecules

Septin-2
Chains: A, B, C, D
Length: 274 amino acids
Theoretical weight: 31.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42208 (Residues: 33-306; Coverage: 76%)
Gene names: Nedd5, Sept2, Septin2
Pfam: Septin
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Septin-2 in PDB entry 3ftq, assembly 1, front view.
Septin-2 in PDB entry 3ftq, assembly 1, side view.
Septin-2 in PDB entry 3ftq, assembly 1, top view.
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