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Crystal structure of Human Brain-type Creatine Kinase

Source organism: Homo sapiens
Biochemical function: ubiquitin protein ligase binding
Biological process: futile creatine cycle
Cellular component: extracellular exosome

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EC 2.7.3.2: Creatine kinase

Reaction catalysed:
ATP + creatine = ADP + phosphocreatine
Systematic name:
ATP:creatine N-phosphotransferase
Alternative Name(s):
  • ATP:creatine phosphotransferase
  • Adenosine triphosphate-creatine transphosphorylase
  • BB-CK
  • CK
  • CK-BB
  • CK-MB
  • CK-MM
  • CKMiMi
  • Creatine phosphokinase
  • Creatine phosphotransferase
  • MB-CK
  • MM-CK
  • Mi-CK
  • MiMi-CK
  • Phosphocreatine kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00217
Domain description: ATP:guanido phosphotransferase, C-terminal catalytic domain
Occurring in:
  1. Creatine kinase B-type
The deposited structure of PDB entry 3b6r contains 2 copies of Pfam domain PF00217 (ATP:guanido phosphotransferase, C-terminal catalytic domain) in Creatine kinase B-type. Showing 1 copy in chain A.

PF02807
Domain description: ATP:guanido phosphotransferase, N-terminal domain
Occurring in:
  1. Creatine kinase B-type
The deposited structure of PDB entry 3b6r contains 2 copies of Pfam domain PF02807 (ATP:guanido phosphotransferase, N-terminal domain) in Creatine kinase B-type. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022414
Domain description: ATP:guanido phosphotransferase, catalytic domain
Occurring in:
  1. Creatine kinase B-type
IPR022413
Domain description: ATP:guanido phosphotransferase, N-terminal
Occurring in:
  1. Creatine kinase B-type
IPR036802
Domain description: ATP:guanido phosphotransferase, N-terminal domain superfamily
Occurring in:
  1. Creatine kinase B-type
IPR022415
Domain description: ATP:guanido phosphotransferase active site
Occurring in:
  1. Creatine kinase B-type
IPR014746
Domain description: Glutamine synthetase/guanido kinase, catalytic domain
Occurring in:
  1. Creatine kinase B-type
IPR000749
Domain description: ATP:guanido phosphotransferase
Occurring in:
  1. Creatine kinase B-type

Structure domains

CATH CATH domains
3.30.590.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Creatine Kinase; Chain A, domain 2
Homology: Glutamine synthetase/guanido kinase, catalytic domain
Occurring in:
  1. Creatine kinase B-type
The deposited structure of PDB entry 3b6r contains 2 copies of CATH domain 3.30.590.10 (Creatine Kinase; Chain A, domain 2) in Creatine kinase B-type. Showing 1 copy in chain A.
1.10.135.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase Creatine Kinase; Chain A, domain 1
Homology: ATP:guanido phosphotransferase, N-terminal domain
Occurring in:
  1. Creatine kinase B-type
The deposited structure of PDB entry 3b6r contains 2 copies of CATH domain 1.10.135.10 (Transferase Creatine Kinase; Chain A, domain 1) in Creatine kinase B-type. Showing 1 copy in chain A.

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