Domain

ATP:guanido phosphotransferase, N-terminal (IPR022413)

Short name: ATP-guanido_PTrfase_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of ATP:guanido phosphotransferase, which has an all-alpha fold consisting of an irregular array of 6 short helices [PMID: 8692275].

ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes [PMID: 2324092, PMID: 7819288] that reversibly catalyse the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include:

  • Glycocyamine kinase (EC:2.7.3.1), which catalyses the transfer of phosphate from ATP to guanidoacetate.
  • Arginine kinase (EC:2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine.
  • Taurocyamine kinase (EC:2.7.3.4), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine.
  • Lombricine kinase (EC:2.7.3.5), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine.
  • Smc74, a cercaria-specific enzyme from Schistosoma mansoni [PMID: 2324092].
  • Creatine kinase (EC:2.7.3.2) (CK) [PMID: 3896131, PMID: 2324105], which catalyses the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP.

Creatine kinase plays an important role in energy metabolism of vertebrates. There are at least four different, but very closely related, forms of CK. Two isozymes, M (muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchins there is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SUPERFAMILY
GENE3D
PROSITE profiles